Phytochemistry 2010-01-01

Three nicotine demethylase genes mediate nornicotine biosynthesis inNicotiana tabacumL.: Functional characterization of theCYP82E10gene

Ramsey S. Lewis, Steven W. Bowen, Matthew R. Keogh, Ralph E. Dewey, Ramsey S. Lewis, Steven W. Bowen, Matthew R. Keogh, Ralph E. Dewey, Ramsey S. Lewis, Steven W. Bowen, Matthew R. Keogh, Ralph E. Dewey

Index: Phytochemistry 71(17-18) , 1988-98, (2010)

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Abstract

Nornicotine is a nicotine metabolite that serves as a precursor in the formation of N′-nitrosonornicotine, a compound shown to be carcinogenic in numerous animal studies. Knocking out the function of all known tobacco N-demethylase genes through targeted mutagenesis is an effective strategy for minimizing the nornicotine content of tobacco.