Bulletin of Experimental Biology and Medicine 2012-08-01

Effects of physicochemical forms of phenazepam and Panavir on their action at ultra-low doses.

S V Stovbun, A V Kiselev, A M Zanin, T S Kalinina, T A Voronina, A I Mikhailov, A A Berlin

Index: Bull. Exp. Biol. Med. 153(4) , 455-8, (2012)

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Abstract

A concept of physicochemical forms of biologically active substances introduced in investigation of the action mechanism of ultra-low doses allows qualitative explanation of the main effects of ultra-low doses, chemical diversity of biologically active substances, and physical boundaries for these effects. Phenazepam was shown to possess activity in ultra-low doses only in disperse state, in the form of nanoparticles with a diameter <100-300 nm; these nanoparticles appear as micelles of surface active substances and solvated. Panavir possesses pharmacological activity in ultra-low doses and appears as nanoparticles with a diameter of 200-300 nm, which have uncompensated negative surface charge and polymer nature.