Farmakologiia i toksikologiia 1980-01-01

[Distribution of 14C-phenazepam and its metabolites in the liver, brain and blood plasma in single and prolonged administration to white rats].

N Ia Golovenko, V G Zin'kovskiĭ, S B Seredenin, S A Andronati, L N Iakubovskaia

Index: Farmakol. Toksikol. 43(2) , 144-8, (1980)

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Abstract

The distribution pattern of 14C-phenazepam and some of its metabolites in the liver, brain and blood plasma at a prolonged (45 days) administration to rats does not differ from that after a single administration. The liver and brain demonstrated an increase in the content of 3-hydroxyderivative. Glycuronide was found only in the liver.