Antimicrobial Agents and Chemotherapy 2009-09-01

Evaluation of analogs of reutericyclin as prospective candidates for treatment of staphylococcal skin infections.

Julian G Hurdle, Raghunandan Yendapally, Dianqing Sun, Richard E Lee

Index: Antimicrob. Agents Chemother. 53 , 4028-31, (2009)

Full Text: HTML

Abstract

The potential for reutericyclin derivatives to be used as topical antibiotics to treat staphylococcal skin infections was investigated. All reutericyclins inhibited the growth of clinical isolates of drug-resistant Staphylococcus aureus. Unlike the standard topical agent mupirocin, most reutericyclin derivatives eradicated staphylococcal biofilms. Moreover, two compounds formulated in hydrophilic petrolatum (10%, wt/wt) were efficacious in treating S. aureus superficial skin infections in mice. These data exemplify the prospect of developing reutericyclins as new topical antibiotics.