In Vivo 2006-01-01

Multidrug resistance reversal by 3-formylchromones in human colon cancer and human mdr1 gene-transfected mouse lymphoma cells.

Zoltán Baráth, Rita Radics, Gabriella Spengler, Imre Ocsovszki, Masami Kawase, Noboru Motohashi, Yoshiaki Shirataki, Anamik Shah, József Molnár

Index: In Vivo 20(5) , 645-9, (2006)

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Abstract

Several new 3-formylchromone derivatives proved to be modifiers of multidrug resistance in mouse lymphoma cells and in human Colo320 colon cancer cells. There is apparently a structure-activity relationship between the antiproliferative multidrug resistance-reversing effect and the chemical structure of the 3-formylchromones. The total polar surface areas and the ground state dipole moments of the molecules are presumed to play a key role in the multidrug resistance-reversing effect. The log P values can provide an adequate explanation for the selective cytotoxicity against cancer cells.