Bioorganic & Medicinal Chemistry 2011-06-01

Discovery of new chromone containing sulfonamides as potent inhibitors of bovine cytosolic carbonic anhydrase.

Mariya al-Rashida, Muhammad Ashraf, Bushra Hussain, Saeed Ahmad Nagra, Ghulam Abbas, Mariya al-Rashida, Muhammad Ashraf, Bushra Hussain, Saeed Ahmad Nagra, Ghulam Abbas

Index: Bioorg. Med. Chem. 19 , 3367-71, (2011)

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Abstract

Series of chromone containing sulfonamides were prepared by the reaction of (un)substituted 3-formylchromones with 3-aminobenzenesulfonamide and 4-aminobenzenesulfonamide. Bovine carbonic anhydrase (bCA) inhibitory activity of these newly synthesized compounds was determined. All compounds were active and possessed excellent bCA inhibitory activities with IC₅₀ values ranged between 4.31 ± 0.001 and 29.12 ± 0.008 μmol. Compounds derived from 6-fluoro-3-formylchromones were the most active.Copyright © 2011 Elsevier Ltd. All rights reserved.