Eksperimental'naia i klinicheskaia farmakologiia 2013-01-01

[Protective effect of cytoflavin and its components in mice with acute alloxan intoxication].

I A Volchegorskiĭ, L M Rassokhina, S G Ermakova, I Iu Miroshnichenko

Index: Eksp. Klin. Farmakol. 76(4) , 26-31, (2013)

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Abstract

We have studied the protective effect of cytoflavin and its components (meglumine sodium succinate, riboflavin, inosine and nicotinamide) in mice with acute alloxan intoxication. It is established that cytoflavin and its components possessing in vitro antioxidant activity (riboflavin, inosine and nicotinamide) significantly decrease the hyperglycemic effect of alloxan. The protective effect of cytoflavin in animals with behavioral disorders caused by acute alloxan intoxication is related to the effect of meglumine sodium succinate and inosine, but does not depend on the influence of these substances on free-radical oxidation processes.