Applied Biochemistry and Biotechnology 2005-07-01

Single-step conversion of cephalosporin-C to 7-aminocephalosporanic acid by free and immobilized cells of Pseudomonas diminuta.

V K Nigam, S Kundu, P Ghosh

Index: Appl. Biochem. Biotechnol. 126(1) , 13-21, (2005)

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Abstract

7-Aminocephalosporanic acid (7-ACA), the starting material for the production of a number of clinically used semisynthetic cephalosporins, is produced by deacylation of cephalosporin-C. The production of 7-ACA was studied in various modes, at the optimal conditions using free and immobilized whole cells of Pseudomonas diminuta.