Phenylureas. Part 1. Mechanism of the basic hydrolysis of phenylureas

R Laudien, R Mitzner

Index: Laudien; Mitzner Journal of the Chemical Society, Perkin Transactions 2, 2001 , # 11 p. 2226 - 2229

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Citation Number: 27

Abstract

The mechanism of the hydrolytic decomposition of phenylureas in basic media in the pH range 12 to 14 is investigated. In this pH range a levelling of the rate–pH curve is observed as well as a change of the substituent influence on the hydrolysis rate. These experimental findings suggest the formation of an unreactive side product of the phenylurea in a parasitic side equilibrium at sufficiently high pH. The urea dissociates at the aryl–NH group to give ...