Phytochemistry

The hydroxylation of some 13α-methylsteroids by Cephalosporium aphidicola

J Boynton, JR Hanson, AC Hunter

Index: Boynton, Juliette; Hanson, James R.; Hunter, A. Christy Phytochemistry, 1997 , vol. 45, # 5 p. 951 - 956

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Citation Number: 17

Abstract

The fungus, Cephalosporium aphidicola, has been shown to hydroxylate 5α, 13α-androstan- 3, 17-dione and the 3β-alcohol at the C-1α and C-7α positions, whereas the corresponding compounds in the normal 13β-methyl series are hydroxylated at the C-11α and C-14α positions. Both series were hydroxylated at the 5α-position. There was some epimerization of the axial 3α-alcohols to the equatorial 3β-epimers.© 1997 Elsevier Science Ltd. All ...