Steroids

The regio-and stereo-selective reduction of steroidal 4-en-3-ones using Na 2 S 2 O 4/NaHCO 3 and CuCl/NaBH 4

C Wang, X Chen, Y Huang, J Yang, Y Chen

Index: Wang, Chunli; Chen, Xiaoyu; Huang, Yaoqing; Yang, Jesse; Chen, Ying Steroids, 2013 , vol. 78, # 14 p. 1339 - 1346

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Citation Number: 2

Abstract

Abstract This paper describes the regio-and stereoselective reduction of△ 4-3-keto moiety in certain steroids using Na 2 S 2 O 4/NaHCO 3 and CuCl/NaBH 4, respectively. Using either one of the two reduction agents in the reaction, the 17-substituents in the D ring were observed to have clearly influenced the stereoselective reduction of 4-ene in the A ring by the so-called conformational transmission effect. Na 2 S 2 O 4/NaHCO 3 regioselectively ...