Steroids

Formation of 5α steroids by biotranformation involving the 5α-reductase activity of Penicillium decumbens

HL Holland, S Dore, X Weili, FM Brown

Index: Holland, Herbert L.; Dore, Sophia; Xu, Weili; Brown, Frances M. Steroids, 1994 , vol. 59, # 11 p. 642 - 647

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Citation Number: 15

Abstract

Abstract The biotransformation of a series of Δ 4-3-ketosteroids by the Penicillium decumbens ATCC 10436 has been investigated. Conversion to the 5α-dihydrosteroid was observed substrates of the androsterone and pregne series: the reaction is tolerant of non- polar substituents (Cl and CH 3) at C-4 of the substrate, but does not occur in the presence of a 4-hydroxyl group, or with additional unsaturation at the Δ 1 orΔ 6 positions. A-nor, B- ...