Food and Chemical Toxicology 2014-06-01

Mutagenicity and genotoxicity studies of arruva, an R,R-monatin salt isomer

Phillip L. Casterton, Witty A. Brathwaite, Christine M. Crincoli

Index: Food Chem. Toxicol. 68 , 30-7, (2014)

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Abstract

• Arruva; i.e., the R,R-isomer of monatin, did not cause bacterial reverse mutations in an Ames assay. • Arruva did not induce mutations in a mouse lymphoma assay. • Arruva did not increase the incidence of micronucleated polychromatic erythrocytes in an in vivo mouse micronucleus assay. • Arruva did not exhibit potential in vitro or in vivo mutagenicity and genotoxicity under the tested conditions.