Synthesis of [3??13C]??,[4??13C]??and [11??13C]??porphobilinogen

…, EAM Schulten, J Lugtenburg

Index: Dawadi, Prativa B. S.; Schulten, Els A. M.; Lugtenburg, Johan Journal of Labelled Compounds and Radiopharmaceuticals, 2009 , vol. 52, # 9 p. 341 - 349

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Citation Number: 2

Abstract

Abstract [4-13 C]-porphobilinogen 1a,[3-13 C]-porphobilinogen 1b and [11-13 C]- porphobilinogen 1c are prepared from [1-13 C]-3-(tetrahydropyran-2′-yloxy)- propionaldehyde 2a, methyl [4-13 C]-4-nitrobutyrate 3b and [1-13 C]-isocyanoacetonitrile 5c, respectively. The building blocks 2, 3 and 5 can be prepared efficiently in any isotopomeric form. Via base-catalyzed condensation of these building blocks porphobilinogen can be ...