Advanced Healthcare Materials 2015-03-11

Inhibition of angiogenesis by antioxidant micelles.

Masaki Moriyama, Stéphanie Metzger, André J van der Vlies, Hiroshi Uyama, Martin Ehrbar, Urara Hasegawa

Index: Adv. Healthc. Mater. 4(4) , 569-75, (2015)

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Abstract

Antioxidant micelles capable of scavenging reactive oxygen species (ROS) are prepared from poly(ethylene glycol)-b-poly(dopamine) block copolymers. The micelles inhibit tube formation of human umbilical vein endothelial cells (HUVECs) by scavenging endogenous ROS. Furthermore, the micelles inhibit angiogenesis in the chicken ex ovo chorioallantoic membrane assay. The results show that antioxidant micelles containing catechol moieties may be useful in anti-angiogenic therapy to treat various diseases such as cancer. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.