Tetrahedron

An eco-benign and highly efficient procedure for N-acylation catalyzed by heteropolyanion-based ionic liquids using carboxylic acid under solvent-free conditions

Z Chen, R Fu, W Chai, H Zheng, L Sun, Q Lu, R Yuan

Index: Chen, Zhikai; Fu, Renzhong; Chai, Wen; Zheng, Hao; Sun, Lin; Lu, Qiang; Yuan, Rongxin Tetrahedron, 2014 , vol. 70, # 13 p. 2237 - 2245

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Citation Number: 15

Abstract

Abstract An eco-benign and highly efficient route for N-acylation of amines has been developed by treating amines with corresponding carboxylic acids in the presence of 2 mol% of heteropolyanion-based ionic liquids as catalysts under solvent-free conditions. This practical reaction could tolerate a wide range of substrates. Thus, various N-acylation products including N-acyl α-amino acid derivatives were obtained in moderate to excellent ...