Deformylation of indole and azaindole-3-carboxaldehydes using anthranilamide and solid acid heterogeneous catalyst via quinazolinone intermediate

…, N Battini, R Mudududdla, JB Bharate, N Muparappu…

Index: Yadav, Rammohan R.; Battini, Narsaiah; Mudududdla, Ramesh; Bharate, Jaideep B.; Muparappu, Nagaraju; Bharate, Sandip B.; Vishwakarma, Ram A. Tetrahedron Letters, 2012 , vol. 53, # 17 p. 2222 - 2225

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Citation Number: 5

Abstract

The deformylation of indole and azaindole-3-carboxaldehydes was achieved in the presence of anthranilamide and a solid acid heterogeneous catalyst under reflux conditions in 25–90% yield. The reaction proceeds via quinazolinone intermediate, which undergoes acid catalyzed cleavage to form deformylated product.

~9%

~67%

~80%

~88%

~65%

~70%

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