Synthesis, in vitro antibacterial and carbonic anhydrase II inhibitory activities of N-acylsulfonamides using silica sulfuric acid as an efficient catalyst under both solvent- …

…, H Adibi, R Khodarahmi, R Abiri, MB Majnooni…

Index: Massah, Ahmad Reza; Adibi, Hadi; Khodarahmi, Reza; Abiri, Ramin; Majnooni, Mohammad Bagher; Shahidi, Sherita; Asadi, Beheshteh; Mehrabi, Masomeh; Zolfigol, Mohammad Ali Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 10 p. 5465 - 5472

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Citation Number: 30

Abstract

Silica sulfuric acid catalyzes efficiently the reaction of sulfonamides with both carboxylic acid anhydrides and chlorides under solvent-free and heterogeneous conditions. All the reactions were done at room temperature and the N-acylsulfonamides were obtained with high yields and purity via an easy work-up procedure. This method is attractive and is in a close agreement with green chemistry. These compounds were also investigated for ...