Synthesis, activity, and molecular modeling studies of novel human aldose reductase inhibitors based on a marine natural product

JÁ de la Fuente, S Manzanaro, MJ Martín…

Index: Cullinane; Davey; Padfield Journal of the Chemical Society, 1934 , p. 716,719

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Citation Number: 47

Abstract

... Journal of Medicinal Chemistry. ... 5,9-11 The most potent and better characterized orally active ARIs belong to two main chemical classes: (i) carboxylic acid derivatives, such as tolrestat, zopolrestat, and zenarestat, and (ii) spiro-hydantoins, such as sorbinil (Figure 1). ...

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