Novel photoaffinity label for the dopamine D2 receptor: synthesis of 4-amino-5-iodo-2-methoxy-N-[1-(phenylmethyl)-4-piperidinyl] benzamide (iodoazidoclebopride, …

…, HB Niznik, A Dumbrille-Ross, P Seeman…

Index: Neumeyer; Guan; Niznik; Dumbrille-Ross; Seeman; Padmanabhan; Elmaleh Journal of Medicinal Chemistry, 1985 , vol. 28, # 4 p. 405 - 407

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Citation Number: 20

Abstract

Conclusion. In the Japanese population, as well as the European and American populations, FH occurs at a frequency of 1 in 500. It is closely associated with premature atherosclerotic heart disease. The increased levels of LDL in FH is believed to accelerate atherosclerosis. FH is a disorder characterized by the defect in LDL receptor, which causes a decrease in LDL uptake by the cell. The decreased LDL uptake, in turn, results in higher ...