2-Nitro analogues of adenosine and 1-deazaadenosine: synthesis and binding studies at the adenosine A 1, A 2A and A 3 receptor subtypes

…, JKVFD Künzel, AP IJzerman, GJ Koomen

Index: Wanner, Martin J.; Von Frijtag Drabbe Kuenzel, Jacobien K.; IJzerman; Koomen, Gerrit-Jan Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 18 p. 2141 - 2144

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Citation Number: 35

Abstract

The influence of nitro substituents on the properties of adenosine and 1-deazaadenosine was studied. Combination of a nitro group at the 2-position with several N6 substituents such as cyclopentyl and m-iodobenzyl gave a series of analogues with good adenosine receptor affinity, showing directable selectivity for the A1, A2A and A3 adenosine receptor subtypes.