A New Method for Synthesis of 2-Alkoxyadenosine Analogs

N Sakakibara, T Tsuruta, M Komatsu, M Iwai…

Index: Sakakibara, Norikazu; Tsuruta, Takashi; Komatsu, Masahiro; Iwai, Masatoshi; Maruyama, Tokumi Heterocycles, 2011 , vol. 83, # 10 p. 2299 - 2311

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Citation Number: 4

Abstract

Abstract – O6-Methylguanosine and 2-amino-6-chloropurine riboside derivative ... Adenosine derivatives comprising 2-alkoxyadenosine groups that have an alkoxy group at the 2-position ... 2-methoxyadenosine, commonly known as spongosine, was isolated from the Caribbean sponge, ... Cryptotethia crypta, in 1951,1 and it has been reported to possess antiviral activity2 and antiplatelet ... Additionally, many of the 2-alkoxyadenosine derivatives, including ...

 Related Synthetic Route
2-(2,6-dimethoxypurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol Structure

88508-72-9

2-(2,6-dimethox...

~70%

spongosine Structure

24723-77-1

spongosine

6-chloro-2-methoxy-9-(β-D-ribofuranosyl)-9H-purine Structure

35109-91-2

6-chloro-2-meth...

~43%

spongosine Structure

24723-77-1

spongosine

2',3',5'-tri-O-(tert-butyldimethylsilyl)-O6-methylguanosine Structure

869477-34-9

2',3',5'-tri-O-...

~%

spongosine Structure

24723-77-1

spongosine

2,6-dimethoxy-9-(2,3-bis-O-tert-butyldimetylsilyl-β-D-ribofuranosyl)-9H-purine Structure

1351797-24-4

2,6-dimethoxy-9...

~%

spongosine Structure

24723-77-1

spongosine

9-((2R,3R,4R,5R)-3,4-bis((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldimethylsilyl)oxy)methyl)tetrahydrofuran-2-yl)-6-chloro-9H-purin-2-amine Structure

141320-73-2

9-((2R,3R,4R,5R...

~%

spongosine Structure

24723-77-1

spongosine

2,6-dimethoxy-9-(2,3-bis-O-tert-butyldimetylsilyl-β-D-ribofuranosyl)-9H-purine Structure

1351797-24-4

2,6-dimethoxy-9...

~99%

2-(2,6-dimethoxypurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol Structure

88508-72-9

2-(2,6-dimethox...

2',3',5'-tri-O-(tert-butyldimethylsilyl)-O6-methylguanosine Structure

869477-34-9

2',3',5'-tri-O-...

~%

2-(2,6-dimethoxypurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol Structure

88508-72-9

2-(2,6-dimethox...


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