Synthetic Communications

Solvent-free esterification of carboxylic acids and alcohols in the presence of Silphos [PCl3-n (SiO2) n] as a heterogeneous phosphine reagent

AN Rao, K Ganesan, CK Shinde

Index: Rao, Ambati Narasimha; Ganesan, Kumaran; Shinde, Chandra Kant Synthetic Communications, 2012 , vol. 42, # 15 p. 2299 - 2308

Full Text: HTML

Citation Number: 5

Abstract

View all references ] Esterification is extensively employed for the protection and further manipulation of the carboxylic acid functional group as well as the synthesis of natural products. Thus esterification of carboxylic acids has been the subject of numerous accounts throughout the years owing to the fundamental importance of this synthetic transformation. Early methods called for heating the carboxylic acid in an alcoholic solvent under acid or base catalysis. Other ...