Synthesis and Antidiabetic Activity of 5, 7??Dihydroxyflavonoids and Analogs

LS Chang, CB Li, N Qin, MN Jin…

Index: Chang, Liu-Shuan; Li, Chun-Bao; Qin, Nan; Jin, Mei-Na; Duan, Hong-Quan Chemistry and Biodiversity, 2012 , vol. 9, # 1 p. 162 - 169

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Citation Number: 7

Abstract

Abstract In a study to evaluate the structural elements essential for the antidiabetic activity of flavonoids, we synthesized two series of flavonoids, 5, 7-dihydroxyflavanones and 5, 7- dihydroxyflavones. In a screening for potential antidiabetic activity, most of the flavonoids showed a remarkable in vitro activity, and compounds 1f, 2d, and 3c were significantly more effective than the positive control, metformin. The biological activity was mainly affected by ...

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