Two routes for the synthesis of the flavones chrysin are described. In the first 1, 3, 5- trimethoxybenzene was converted to 2-hydroxy-4, 6-dimethoxyacetophenone and then by condensation with benzaldehyde to 2′-hydroxy-4′, 6′-dimethoxychalcone. The latter was cyclised with iodine and demethylated with pyridine hydrochloride to form chrysin in 53% overall yield. In the second route, 1, 3, 5-trimethoxybenzene was acylated with ...
