Tetrahedron letters

Formation of the unexpected 3-alkylated flavonoids in the alkylation of B-ring substituted 5, 7-dihydroxy flavones

CL Wang, X Zheng, WD Meng, HQ Li, FL Qing

Index: Wang, Cai-Ling; Zheng, Xing; Meng, Wei-Dong; Li, Hong-Qi; Qing, Feng-Ling Tetrahedron Letters, 2005 , vol. 46, # 32 p. 5399 - 5402

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Citation Number: 10

Abstract

Treatment of B-ring substituted 5, 7-dihydroxy flavones with alkyl halides in the presence of potassium carbonate gave unexpected 3-alkylated flavonoids. Related experiments were carried out to explain the formation of 3-alkylated flavonoids and a ring opening followed by alkylation and ring closure mechanism was proposed.