… determination of 2??arachidonoylglycerol, 1??arachidonoylglycerol and arachidonic acid in mouse brain tissue using liquid chromatography/tandem mass spectrometry

…, J Btesh, N Kagan, E Kerns, TA Samad…

Index: Zhang, Mei-Yi; Gao, Ying; Btesh, Joan; Kagan, Natasha; Kerns, Edward; Samad, Tarek A.; Chanda, Pranab K. Journal of Mass Spectrometry, 2010 , vol. 45, # 2 p. 167 - 177

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Citation Number: 16

Abstract

Abstract Endocannabinoids (ECs), such as anandamide (AEA) and 2-arachidonoylglycerol (2-AG), modulate a number of physiological processes, including pain, appetite and emotional state. Levels of ECs are tightly controlled by enzymatic biosynthesis and degradation in vivo. However, there is limited knowledge about the enzymes that terminate signaling of the major brain EC, 2-AG. Identification and quantification of 2-AG, 1-AG and ...