… determination of 2??arachidonoylglycerol, 1??arachidonoylglycerol and arachidonic acid in mouse brain tissue using liquid chromatography/tandem mass spectrometry
…, J Btesh, N Kagan, E Kerns, TA Samad…
文献索引:Zhang, Mei-Yi; Gao, Ying; Btesh, Joan; Kagan, Natasha; Kerns, Edward; Samad, Tarek A.; Chanda, Pranab K. Journal of Mass Spectrometry, 2010 , vol. 45, # 2 p. 167 - 177
Abstract Endocannabinoids (ECs), such as anandamide (AEA) and 2-arachidonoylglycerol (2-AG), modulate a number of physiological processes, including pain, appetite and emotional state. Levels of ECs are tightly controlled by enzymatic biosynthesis and degradation in vivo. However, there is limited knowledge about the enzymes that terminate signaling of the major brain EC, 2-AG. Identification and quantification of 2-AG, 1-AG and ...