Amide Formation in One Pot from Carboxylic Acids and Amines via Carboxyl and Sulfinyl Mixed Anhydrides

…, SR Dubbaka, D Markovic, E Moreno-Clavijo…

Index: Zambron, Bartosz K.; Dubbaka, Srinivas R.; Markovic, Dean; Moreno-Clavijo, Elena; Vogel, Pierre Organic Letters, 2013 , vol. 15, # 10 p. 2550 - 2553

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Citation Number: 9

Abstract

An efficient method has been developed for the preparation of yet unknown acyclic mixed anhydrides of carboxylic and sulfinic acids. Sterically hindered 2-methylbut-3-ene-2-sulfinyl carboxylates add primary and secondary amines preferentially onto the carbonyl moieties realizing a new method for the one-pot preparation of carboxamides. It uses 1: 1 mixtures of carboxylic acids and amines without a base, requires no excess of reagents, and liberates ...