Facile Synthesis and Biological Evaluation of Substituted 5-(1H-Indol-3-ylmethylene) pyrimidine-2, 4, 6-trione Derivatives Using L-Tyrosine in Aqueous Medium

G Thirupathi, PK Dubey…

Index: Thirupathi; Dubey; Kumari, Y. Bharathi Asian Journal of Chemistry, 2013 , vol. 25, # 15 p. 8741 - 8748

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Abstract

Abstract L-Tyrosine as an efficient catalyst for the Knoevenagel condensation of substituted indole-3-aldehydes 1 (ad), N-methyl indole-3-aldehydes 4 (ad), N-ethyl indole-3-aldehydes 6 (ad) with barbituric acid (2) containing cyclic active methylene group to produce 3 (ad), 5 (ad) and 7 (ad), respectively in water at room temperature for 10 min. The antimicrobial activities of 3 (ad), 5 (ad) and 7 (ad) have been studied.