Synthesis and antiviral activity of 4-benzyl pyridinone derivatives as potent and selective non-nucleoside human immunodeficiency virus type 1 reverse transcriptase …

…, M Ventura, L Tarrago-Litvak, E Bisagni

Index: Bisagni, Emile; Rautureau, Marilys; Huel, Christiane Heterocycles, 1988 , vol. 27, # 7 p. 1671 - 1678

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Citation Number: 32

Abstract

Several 4-benzyl analogues of 5-ethyl-6-methyl-4-(phenylthio) pyridin-2 (1 H)-ones were synthesized and evaluated for their anti-HIV-l activities. Key transformations include metalation at the 4-C-position of 5-ethyl-2-methoxy-6-methyl-3-pivaloylaminopyridine (5)