A series of imidazo [1, 2-a] pyrazine derivatives was synthesized by condensation of a- halogenocarbonyl compounds and aminopyrazines. Various compounds resulted from competitive reactions or reagent isomerization and demonstrated in vitro uterine-relaxing and in vivo antibronchospastic activities. On isolated atria, 5-bromoimidazo-[1, 2-a] pyrazine showed positive chronotropic and inotropic properties; the latter was associated with an ...