Chemical research in toxicology

Syntheses and properties of 1-methyl-3-phenylaminobenzimidazolium salts, models of DNA adducts of N7-arylaminodeoxyguanosinium salt

T Kaiya, T Fujiwara, K Kohda

Index: Kohda, Kohfuku; Baba, Kunihisa; Kawazoe, Yutaka Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 5 p. 2298 - 2301

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Citation Number: 15

Abstract

When arylaminating carcinogens are administered to cells, they mainly generate the C8- arylamino-2'-deoxyguanosine adduct in DNA. A mechanism for this was proposed in which N7-arylaminated 2'-deoxyguanosine acts as an intermediate; however, it remained unclear