Design, synthesis, antibacterial, and QSAR studies of myristic acid derivatives

B Narasimhan, V Mourya, A Dhake

Index: Narasimhan, Balasubramanian; Mourya, Vishnukant; Dhake, Avinash Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 11 p. 3023 - 3029

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Citation Number: 44

Abstract

A series of esters and amides of myristic acid was synthesized and tested in vitro for antibacterial activity against Gram-positive and Gram-negative bacteria. All the compounds showed activity comparable to that of the standard drug, ciprofloxacin. The structural characteristics governing antibacterial activity of myristic acid derivatives was studied using QSAR methodology. The results showed that the antibacterial activity could be modeled ...