Direct Hydrogenation of Carboxylic Acids to Corresponding Aldehydes Catalyzed by Palladium Complexes.

K Nagayama, I Shimizu, A Yamamoto

Index: Nagayama; Shimizu; Yamamoto Bulletin of the Chemical Society of Japan, 2001 , vol. 74, # 10 p. 1803 - 1815

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Citation Number: 46

Abstract

A variety of carboxylic acids can be directly hydrogenated into the corresponding aldehydes in high yields by using homogeneous catalysts such as [Pd (PPh 3) 4] or combination of Pd (OAc) 2 with tertiary phosphines in the presence of an excess amount of 2, 2- dimethylpropionic anhydride (pivalic anhydride). As a typical example, octanoic acid can be converted into octanal in 99% yield in 3 h at 80° C under 3.0 MPa of H 2 in acetone in the ...