Palladium-Catalyzed Borylation of Phenyl Bromides and Application in One-Pot Suzuki-Miyaura Biphenyl Synthesis

…, I Cerna, M Campaniello, F Leroux, F Colobert

Index: Broutin, Pierre-Emmanuel; Cerna, Igor; Campaniello, Maria; Leroux, Frederic; Colobert, Francoise Organic Letters, 2004 , vol. 6, # 24 p. 4419 - 4422

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Citation Number: 97

Abstract

The coupling reaction of pinacolborane with various aryl bromides in the presence of a catalytic amount of Pd (OAc) 2 together with DPEphos as ligand and Et3N as base provided arylboronates. High yields were obtained in the case of electron-donor substituted aryl bromides. The direct preparation of arylboronates allowed the one-pot, two-step synthesis of unsymmetrical biaryls in high yields.