Tetrahedron

Synthesis of pinacol arylboronates via cross-coupling reaction of bis (pinacolato) diboron with chloroarenes catalyzed by palladium (0)–tricyclohexylphosphine …

T Ishiyama, K Ishida, N Miyaura

Index: Ishiyama, Tatsuo; Ishida, Kousaku; Miyaura, Norio Tetrahedron, 2001 , vol. 57, # 49 p. 9813 - 9816

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Citation Number: 256

Abstract

The cross-coupling reaction of bis (pinacolato) diboron with chloroarenes to yield pinacol arylboronates was carried out in 1, 4-dioxane at 80° C in the presence of KOAc (1.5 equiv.) and Pd (dba) 2/2.4 PCy3 (3–6mol%). The catalyst was also effective to carry out analogous coupling with aryl bromides or triflates under milder conditions than those of the previous procedures catalyzed by PdCl2 (dppf) in DMSO.