Synthesis and antifungal activity of novel (1-aryl-2-heterocyclyl) ethylideneaminooxymethyl-substituted dioxolanes

H Baji, M Flammang, T Kimny, F Gasquez…

Index: Baji, H.; Flammang, M.; Kimny, T.; Gasquez, F.; Compagnon, P. L.; Delcourt, A. European Journal of Medicinal Chemistry, 1995 , vol. 30, # 7-8 p. 617 - 626

Full Text: HTML

Citation Number: 28

Abstract

A novel series of (1-aryl-2-heterocyclyl) ethylideneaminooxymethyl-substituted dioxolanes IIIa-n were synthesized by condensation of substituted 1, 3-dioxolan-4-ylmethyl p- toluenesulfonates 4 with l-(hydroxyimino)-1-aryl-2-heterocyclylethanes 5. Compounds IIIa-n were found to have effective in vitro antifungal activity when evaluated against the pathogenic fungi Candida albicans, Aspergillus flavus and Fusarium solani with MIC ( ...

 Related Synthetic Route
1,2,4-Triazole Structure

288-88-0

1,2,4-Triazole

2-Bromo-2',4'-dichloroacetophenone Structure

2631-72-3

2-Bromo-2',4'-d...

~78%

ETHANONE, 1-(2,4-DICHLOROPHENYL)-2-(1H-1,2,4-TRIAZOL-1-YL)- Structure

58905-16-1

ETHANONE, 1-(2,...

Solketal Structure

100-79-8

Solketal

~%

4-[(Aminooxy)methyl]-2,2-dimethyl-1,3-dioxolane Structure

391212-32-1

4-[(Aminooxy)me...

1,2,4-Triazole Structure

288-88-0

1,2,4-Triazole

2-Bromo-4'-chloroacetophenone Structure

536-38-9

2-Bromo-4'-chlo...

~84%

1-(4-CHLOROPHENYL)-2-(1H-1,2,4-TRIAZOLE-1-YL)-ETHANONE Structure

58905-19-4

1-(4-CHLOROPHEN...


Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved