Design, synthesis and evaluation of clinafloxacin triazole hybrids as a new type of antibacterial and antifungal agents

Y Wang, GLV Damu, JS Lv, RX Geng, DC Yang…

Index: Wang, Yan; Damu, Guri L.V.; Lv, Jing-Song; Geng, Rong-Xia; Yang, Da-Cheng; Zhou, Cheng-He Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 17 p. 5363 - 5366

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Citation Number: 42

Abstract

A series of clinafloxacin triazole hybrids as a new type of antibacterial and antifungal agents were synthesized for the first time and screened for their antimicrobial efficacy against four Gram-positive bacteria, four Gram-negative bacteria and two fungi by two fold serial dilution technique. The bioactive assay indicated that most of the target compounds displayed broad antimicrobial spectrum and good antibacterial and antifungal activities with low MIC ...