Synthesis and antifungal activity of novel (1-aryl-2-heterocyclyl) ethylideneaminooxymethyl-substituted dioxolanes

H Baji, M Flammang, T Kimny, F Gasquez…

文献索引：Baji, H.; Flammang, M.; Kimny, T.; Gasquez, F.; Compagnon, P. L.; Delcourt, A. European Journal of Medicinal Chemistry, 1995 , vol. 30, # 7-8 p. 617 - 626

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被引用次数: 28

摘要

A novel series of (1-aryl-2-heterocyclyl) ethylideneaminooxymethyl-substituted dioxolanes IIIa-n were synthesized by condensation of substituted 1, 3-dioxolan-4-ylmethyl p- toluenesulfonates 4 with l-(hydroxyimino)-1-aryl-2-heterocyclylethanes 5. Compounds IIIa-n were found to have effective in vitro antifungal activity when evaluated against the pathogenic fungi Candida albicans, Aspergillus flavus and Fusarium solani with MIC ( ...