Synthesis of 1-alkyl-1, 2, 4-triazoles: a new one-pot regiospecific procedure

BA Astleford, GL Goe, JG Keay…

文献索引：Astleford, Bret A.; Goe, Gerald L.; Keay, James G.; Scriven, Eric F. V. Journal of Organic Chemistry, 1989 , vol. 54, # 3 p. 731 - 732

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被引用次数: 46

摘要

Regiospecific alkylation of 1, 2, 4-triazoles provides a synthetic challenge. 2 Direct alkylation of 1, 2, 4-triazole affords usually a mixture of mainly 1-and some 4-substituted pr~ duct.~ Ratios vary with the nature of the alkylating agent and conditions but frequently range from 70: 30 to 9010. Preparation of 1-substituted 1, 2, 4-triazoles has become important of late, as a number of such triazoles has been found to be very effective agricultural fungicides? ...