2-Bromo-4'-chloroacetophenone

Modify Date: 2024-01-02 17:00:49

2-Bromo-4'-chloroacetophenone Structure
2-Bromo-4'-chloroacetophenone structure
Common Name 2-Bromo-4'-chloroacetophenone
CAS Number 536-38-9 Molecular Weight 233.490
Density 1.6±0.1 g/cm3 Boiling Point 289.7±15.0 °C at 760 mmHg
Molecular Formula C8H6BrClO Melting Point 95-99ºC
MSDS Chinese USA Flash Point 129.0±20.4 °C
Symbol GHS05
GHS05
Signal Word Danger

 Names

Name 2-Bromo-4’-chloroacetophenone
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.6±0.1 g/cm3
Boiling Point 289.7±15.0 °C at 760 mmHg
Melting Point 95-99ºC
Molecular Formula C8H6BrClO
Molecular Weight 233.490
Flash Point 129.0±20.4 °C
Exact Mass 231.929047
PSA 17.07000
LogP 2.88
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.584

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AM5978800
CHEMICAL NAME :
Acetophenone, 2-bromo-4'-chloro-
CAS REGISTRY NUMBER :
536-38-9
BEILSTEIN REFERENCE NO. :
0607603
LAST UPDATED :
199709
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C8-H6-Br-Cl-O
MOLECULAR WEIGHT :
233.50

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MEXPAG Medicina Experimentalis. (Basel, Switzerland) V.1-11, 1959-64; V.18-19, 1968-69. For publisher information, see JNMDBO. Volume(issue)/page/year: 11,137,1964

 Safety Information

Symbol GHS05
GHS05
Signal Word Danger
Hazard Statements H314
Precautionary Statements P280-P305 + P351 + P338-P310
Personal Protective Equipment Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes C:Corrosive;
Risk Phrases R22;R34
Safety Phrases S26-S36/37/39-S45
RIDADR UN 3261 8/PG 2
WGK Germany 2
RTECS AM5978800
Packaging Group III
HS Code 2914399090

 Synthetic Route

 Customs

HS Code 2914399090
Summary 2914399090. other aromatic ketones without other oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

 Articles2

More Articles
Design, synthesis and structure-activity relationship studies of novel and diverse cyclooxygenase-2 inhibitors as anti-inflammatory drugs.

J. Enzyme Inhib. Med. Chem. 29(6) , 846-67, (2014)

Because of the pivotal role of cyclooxygenase (COX) in the inflammatory processes, non-steroidal anti-inflammatory drugs (NSAIDs) that suppress COX activities have been used clinically for the treatme...

Switching reversibility to irreversibility in glycogen synthase kinase 3 inhibitors: clues for specific design of new compounds.

J. Med. Chem. 54 , 4042-56, (2011)

Development of kinase-targeted therapies for central nervous system (CNS) diseases is a great challenge. Glycogen synthase kinase 3 (GSK-3) offers a great potential for severe CNS unmet diseases, bein...

 Synonyms

α-Bromo-p-chloroacetophenone
MFCD00000625
Ethanone, 2-bromo-1-(4-chlorophenyl)-
ω-Bromo-4-chloroacetophenone
2-Bromo-4‘-chloroacetophenone
2-Bromo-4'-chloroacetophenone
α-Bromo-4-chloroacetophenone
4'-Chloro-2-Bromoacetophenone
4-Chlorophenacyl Bromide
EINECS 208-631-5
2-Bromo-1-(4-chlorophenyl)ethanone
Ethanone, 2-bromo-1- (4-chlorophenyl)-
α-Bromo-4'-chloroacetophenone
2-bromo-1-(4-chlorophenyl)ethan-1-one