Synlett

Organic reactions in water: A practical and convenient method for the N-formylation of amines in water

B Kaboudin, M Khodamorady

Index: Kaboudin, Babak; Khodamorady, Minoo Synlett, 2010 , # 19 p. 2905 - 2907

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Citation Number: 6

Abstract

Abstract A simple, efficient, scaleable process has been developed for the N-formylation amines in water. Treatment of amines with triethyl orthoformate in water at reflux under neutral conditions without any additives gives the corresponding N-formyl derivatives in good yields.

~64%

~51%

~62%

~59%

~51%

~42%

~41%

~83%

~78%

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