Catalytic Three??Component Domino Reaction for the Preparation of Trisubstituted Oxazoles

…, F Paulsen, N Loganathan, D Strand

Index: Wachenfeldt, Henrik V.; Roese, Philipp; Paulsen, Filip; Loganathan, Nagarajan; Strand, Daniel Chemistry - A European Journal, 2013 , vol. 19, # 24 p. 7982 - 7988

Full Text: HTML

Citation Number: 22

Abstract

Abstract Multicomponent reactions are attractive for assembling functionalized heterocyclic compounds. To this end, an efficient gold-catalyzed three-component domino reaction to form oxazoles directly from imines, alkynes, and acid chlorides is presented. The reaction proceeds in a single synthetic step by using a gold (III)–N, N′-ethylenebis (salicylimine)(salen) catalyst to give trisubstituted oxazoles in up to 96% yield. The ...

Catalytic monoalkylation of 1, 2-diols

[Maki, Toshihide; Ushijima, Nobuto; Matsumura, Yoshihiro; Onomura, Osamu Tetrahedron Letters, 2009 , vol. 50, # 13 p. 1466 - 1468]

… Approach to the Synthesis of Taxol. A Synthesis of Optical...

[Mukaiyama, Teruaki; Shiina, Isamu; Sakata, Kaku; Emura, Takayuki; Seto, Keitarou; Saitoh, Masahiro Chemistry Letters, 1995 , # 3 p. 179 - 180]

Enantioselective total synthesis of epothilones A and B usin...

[Sawada, Daisuke; Kanai, Motomu; Shibasaki, Masakatsu Journal of the American Chemical Society, 2000 , vol. 122, # 43 p. 10521 - 10532]

Approaches to the synthesis of enantiopure α-hydroxy-β-lacta...

[Yang, Yan; Wang, Jianmei; Kayser, Margaret Tetrahedron Asymmetry, 2007 , vol. 18, # 17 p. 2021 - 2029]