Enantioselective total synthesis of epothilones A and B using multifunctional asymmetric catalysis

D Sawada, M Kanai, M Shibasaki

Index: Sawada, Daisuke; Kanai, Motomu; Shibasaki, Masakatsu Journal of the American Chemical Society, 2000 , vol. 122, # 43 p. 10521 - 10532

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Citation Number: 132

Abstract

An enantioselective total synthesis of epothilones A (1) and B (2) using multifunctional asymmetric catalysis such as a cyanosilylation of an aldehyde, an aldol reaction of an unmodified ketone with an aldehyde, and a protonation in the conjugate addition of a thiol to an α, β-unsaturated thioester has been achieved. We divided 1 and 2 into fragment A, fragment B, and fragment C. A catalytic asymmetric synthesis of fragments A and B was ...

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