Alkyne Metathesis: Development of a Novel Molybdenum??Based Catalyst System and Its Application to the Total Synthesis of Epothilone A and C

…, C Mathes, CW Lehmann

Index: Fuerstner, Alois; Mathes, Christian; Lehmann, Christian W. Chemistry - A European Journal, 2001 , vol. 7, # 24 p. 5299 - 5317

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Citation Number: 218

Abstract

Abstract Sterically hindered molybdenum (III) amido complexes of the general type [Mo {(tBu)(Ar) N} 3](1), upon treatment with CH 2 Cl 2 or other halogen donors, have been converted into highly effective catalysts for all kinds of alkyne metathesis reactions. Although the actual nature of the propagating species formed in situ is still elusive, halogen transfer to the Mo center of 1 plays a decisive role in the activation of such precatalysts. It was ...

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(2E)-2-Methyl-3-(2-methyl-1,3-thiazol-4-yl)acrylaldehyde Structure

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(2E)-2-Methyl-3...

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EPOTHILONE C Structure

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EPOTHILONE C

(3S)-2-methyl-1-(2-methyl-1,3-thiazol-4-yl)hexa-1,5-dien-3-ol Structure

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EPOTHILONE C Structure

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EPOTHILONE C

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(3S,4E)-3-{[ter...

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EPOTHILONE C Structure

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EPOTHILONE C

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EPOTHILONE C Structure

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EPOTHILONE C

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EPOTHILONE C Structure

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EPOTHILONE C

(S)-2-methyl-oct-6-ynal Structure

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EPOTHILONE C Structure

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EPOTHILONE C

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EPOTHILONE C Structure

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EPOTHILONE C

2-[(3S)-2,2-dimethyl-1,3-dioxan-4-yl]-2-methylpropionic ethyl ester Structure

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EPOTHILONE C Structure

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EPOTHILONE C

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EPOTHILONE C Structure

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EPOTHILONE C

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EPOTHILONE C Structure

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EPOTHILONE C

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EPOTHILONE C Structure

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EPOTHILONE C

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EPOTHILONE C Structure

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EPOTHILONE C

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EPOTHILONE C Structure

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EPOTHILONE C

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EPOTHILONE C Structure

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EPOTHILONE C

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EPOTHILONE C Structure

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EPOTHILONE C

(3S,6R,7S,8S)-3,7-bis-(tert-butyldimethylsilanyloxy)-1-hydroxy-4,4,6,8-tetramethyl-tetradec-12-yne-5-one Structure

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EPOTHILONE C Structure

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EPOTHILONE C

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EPOTHILONE C Structure

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EPOTHILONE C

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EPOTHILONE C Structure

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EPOTHILONE C

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EPOTHILONE C Structure

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EPOTHILONE C

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EPOTHILONE C Structure

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EPOTHILONE C Structure

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EPOTHILONE C

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