Catalytic Three??Component Domino Reaction for the Preparation of Trisubstituted Oxazoles

…, F Paulsen, N Loganathan, D Strand

文献索引：Wachenfeldt, Henrik V.; Roese, Philipp; Paulsen, Filip; Loganathan, Nagarajan; Strand, Daniel Chemistry - A European Journal, 2013 , vol. 19, # 24 p. 7982 - 7988

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被引用次数: 22

摘要

Abstract Multicomponent reactions are attractive for assembling functionalized heterocyclic compounds. To this end, an efficient gold-catalyzed three-component domino reaction to form oxazoles directly from imines, alkynes, and acid chlorides is presented. The reaction proceeds in a single synthetic step by using a gold (III)–N, N′-ethylenebis (salicylimine)(salen) catalyst to give trisubstituted oxazoles in up to 96% yield. The ...

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