Chemistry Letters

… Approach to the Synthesis of Taxol. A Synthesis of Optically Active 3, 7-dibenzyloxy-4, 8-di-t-butyl-dimethylsiloxy-5, 5-dimethyl-6-p-methoxybenzyloxy-2-octanone by …

T Mukaiyama, I Shiina, K Sakata, T Emura, K Seto…

Index: Mukaiyama, Teruaki; Shiina, Isamu; Sakata, Kaku; Emura, Takayuki; Seto, Keitarou; Saitoh, Masahiro Chemistry Letters, 1995 , # 3 p. 179 - 180

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Citation Number: 16

Abstract

抄録 Optically active 3, 7-dibenzyloxy-4, 8-di- t-butyldimethylsiloxy-5, 5-dimethyl-6- p-methoxybenzyloxy-2-octanone ( 2) has been synthesized by way of diastereoselective aldol reaction between 4-benzyloxy-5- t-butyldimethylsiloxy-2, 2- dimethyl-3- p-methoxy-benzyloxypentanal ( 3) and ketene silyl acetal 4 using MgBr 2· OEt 2 as a catalyst. The chiral ...

~92%

~96%

Catalytic monoalkylation of 1, 2-diols

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