Mechanism of toxicity of esters of caffeic and dihydrocaffeic acids

B Etzenhouser, C Hansch, S Kapur…

Index: Etzenhouser, Beth; Hansch, Corwin; Kapur, Sanjay; Selassie Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 1 p. 199 - 209

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Citation Number: 64

Abstract

Ten esters each of caffeic acid and dihydrocaffeic acid have recently been synthesized. Cytotoxicity evaluations of these esters versus L1210 leukemia and MCF-7 breast cancer cells in culture have led to the delineation of substantially different QSAR for each series. The L1210 QSAR for dihydrocaffeic acid esters resembles the QSAR obtained for simple phenols and estrogenic phenols. However, the QSAR pertaining to the caffeic acid esters ...