Mechanism of toxicity of esters of caffeic and dihydrocaffeic acids

B Etzenhouser, C Hansch, S Kapur…

文献索引：Etzenhouser, Beth; Hansch, Corwin; Kapur, Sanjay; Selassie Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 1 p. 199 - 209

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被引用次数: 64

摘要

Ten esters each of caffeic acid and dihydrocaffeic acid have recently been synthesized. Cytotoxicity evaluations of these esters versus L1210 leukemia and MCF-7 breast cancer cells in culture have led to the delineation of substantially different QSAR for each series. The L1210 QSAR for dihydrocaffeic acid esters resembles the QSAR obtained for simple phenols and estrogenic phenols. However, the QSAR pertaining to the caffeic acid esters ...